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Toxicol Lett. 2016 Sep 30;259:21-27. doi: 10.1016/j.toxlet.2016.06.1122. Epub 2016 Jun 23.

Nephrotoxicity in rabbits after long-term nandrolone decanoate administration.

Author information

1
Department of Dangerous Substances, Mixtures and Articles, Directorate of Environment, General Chemical State Laboratory of Greece, Athens, Greece.
2
Center of Toxicology Science & Research, Medical School, University of Crete, Heraklion, Crete, Greece.
3
Department of Cardiology, University Hospital of Larissa, Thessaly Prefecture, Larissa, Greece.
4
Department of Pathology, Medical School, University of Crete, Heraklion, Crete, Greece.
5
Department of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece.
6
Department of Pathology, University Hospital of Larissa, Thessaly Prefecture, Larissa, Greece.
7
Department of Urology, University Hospital of Heraklion, Crete, Greece.
8
Center of Toxicology Science & Research, Medical School, University of Crete, Heraklion, Crete, Greece. Electronic address: toxlab@med.uoc.gr.

Abstract

Among the various side effects of supra-physiological dose of anabolic androgenic steroids that are described, renal toxicity remains the least evaluated. The present study provides evidence that long-term administration of nandrolone decanoate could lead to alterations of renal function and structure in the experimental rabbit model. A pronounced increase in serum urea, creatinine, SGOT and SGPT is observed in the treated animals, with intramuscular administration being more detrimental. Histopathological evaluation of kidneys indicated hyperaemia, fibrosis and focal inflammation. Furthermore, the significantly increased telomerase activity found in the kidneys of the intramuscularly treated animals could possibly represent a counteracting survival mechanism. Oxidative stress markers that were influenced the most were TBARS, indicating lipid peroxidation, and GSH. An interesting finding in our study though, was that while intramuscular administration showed the highest biochemical derangement, oxidative stress markers provided mixed results between intramuscularly and subcutaneously treated rabbits. In conclusion, nephrotoxicity of nandrolone decanoate remains a multi-factorial, partly irreversible effect that involves augmented tissue oxidative status.

KEYWORDS:

Creatinine; Kidney; Nandrolone; Oxidative stress; Urea

PMID:
27346656
DOI:
10.1016/j.toxlet.2016.06.1122
[Indexed for MEDLINE]

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