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Sci Rep. 2016 Jun 27;6:28484. doi: 10.1038/srep28484.

Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls.

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Division of Biomedical Statistics and Informatics-Department of Health Sciences Research Mayo Clinic, 200 1st ST SW, Rochester, MN -55905, USA.
Department of Surgical Research Mayo Clinic, 200 1st ST SW, Rochester, MN -55905, USA.
Department of Biophysics Mayo Clinic, 200 1st ST SW, Rochester, MN -55905, USA.
Mayo Clinic Center for Multiple Sclerosis and CNS Demyelinating Diseases, Department of Neurology, Mayo Clinic College of Medicine, 200 1st ST SW, Rochester, MN-55905, USA.
International Clinical Research Center, St. Anne's University Hospital Brno, Pekařská 53, 656 91 Brno, Czech Republic.
Department of Immunology Mayo Clinic, 200 1st ST SW, Rochester, MN -55905, USA.
Department of Gastroenterology, Mayo Clinic, Rochester, MN-55905, USA.
Department of Pathology, 25 S Grand Ave, 1080-ML, University of Iowa, Iowa City, IA-52242, USA.


Multiple sclerosis (MS) is an immune-mediated disease, the etiology of which involves both genetic and environmental factors. The exact nature of the environmental factors responsible for predisposition to MS remains elusive; however, it's hypothesized that gastrointestinal microbiota might play an important role in pathogenesis of MS. Therefore, this study was designed to investigate whether gut microbiota are altered in MS by comparing the fecal microbiota in relapsing remitting MS (RRMS) (n = 31) patients to that of age- and gender-matched healthy controls (n = 36). Phylotype profiles of the gut microbial populations were generated using hypervariable tag sequencing of the V3-V5 region of the 16S ribosomal RNA gene. Detailed fecal microbiome analyses revealed that MS patients had distinct microbial community profile compared to healthy controls. We observed an increased abundance of Psuedomonas, Mycoplana, Haemophilus, Blautia, and Dorea genera in MS patients, whereas control group showed increased abundance of Parabacteroides, Adlercreutzia and Prevotella genera. Thus our study is consistent with the hypothesis that MS patients have gut microbial dysbiosis and further study is needed to better understand their role in the etiopathogenesis of MS.

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