Format

Send to

Choose Destination
Obesity (Silver Spring). 2016 Jul;24(7):1546-53. doi: 10.1002/oby.21511.

Greater early and mid-pregnancy gestational weight gains are associated with excess adiposity in mid-childhood.

Author information

1
Department of Population Medicine, Obesity Prevention Program, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA.
2
Diabetes Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.
3
Department of Medicine, Université de Sherbrooke, Sherbrooke, Canada.

Abstract

OBJECTIVE:

It is unclear how specific periods of gestational weight gain (GWG) during pregnancy relate to childhood adiposity. The goal of this study was to assess the differential impact of GWG timing on childhood body composition.

METHODS:

In 979 mother-child pairs from the pre-birth Project Viva cohort, trimester-specific GWG was calculated using clinically recorded weights. Outcomes included body mass index (BMI) z-score, dual X-ray absorptiometry fat mass index (kg/m(2) ), and fat-free mass index (kg/m(2) ) in mid-childhood. Linear regression models were used to assess associations of each trimester's GWG (per 0.2 kg/week) with childhood outcomes, adjusted for maternal prepregnancy BMI, sociodemographic variables, lifestyle, and GWG in prior trimester(s).

RESULTS:

Mean (SD) first trimester GWG was 0.22 (0.22) kg/week, second trimester 0.49 (0.18) kg/week, and third trimester 0.47 (0.20) kg/week. Faster first trimester GWG was associated with higher BMI z-score (0.06 units [95% CI: 0.01-0.12] per 0.2 kg/week) and with higher adiposity according to all indices; associations were strongest in women with prepregnancy BMI >30 kg/m(2) . Faster second trimester GWG was associated with higher BMI z-score (0.11 [0.04-0.18]), fat mass (fat mass index = 0.16 [0.02-0.31] kg/m(2) ), and lean mass (fat-free mass index = 0.11 [0.01-0.22] kg/m(2) ). Third trimester GWG was not associated with childhood adiposity.

CONCLUSIONS:

These results reinforce the importance of addressing appropriate GWG in early pregnancy.

PMID:
27345963
PMCID:
PMC4968400
DOI:
10.1002/oby.21511
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center