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Semin Perinatol. 2016 Oct;40(6):385-390. doi: 10.1053/j.semperi.2016.05.009. Epub 2016 Jun 23.

Hypothermia for neonatal hypoxic-ischemic encephalopathy: NICHD Neonatal Research Network contribution to the field.

Author information

1
Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, 3901 Beaubien Blvd, Detroit, MI 48201. Electronic address: sshankar@med.wayne.edu.
2
Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, 3901 Beaubien Blvd, Detroit, MI 48201.
3
Department of Pediatrics, University of Texas Southwestern, Dallas, TX.
4
Statistics and Epidemiology Unit, RTI International, Research Triangle Park, Durham, NC.
5
Department of Pediatrics, Brown University, Providence, RI.

Abstract

In this article, we summarize the NICHD Neonatal Research Network (NRN) trial of whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy in relation to other randomized controlled trials (RCTs) of hypothermia neuroprotection. We describe the NRN secondary studies that have been published in the past 10 years evaluating clinical, genetic, biochemical, and imaging biomarkers of outcome.

KEYWORDS:

Biomarkers; Hypothermia Neuroprotection; Hypoxic-ischemic encephalopathy; Neonatal

PMID:
27345952
PMCID:
PMC5065734
DOI:
10.1053/j.semperi.2016.05.009
[Indexed for MEDLINE]
Free PMC Article

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