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Biochim Biophys Acta. 2016 Aug;1866(1):64-75. doi: 10.1016/j.bbcan.2016.06.002. Epub 2016 Jun 21.

Chromosomal instability: A common feature and a therapeutic target of cancer.

Author information

1
Department of Molecular Oncology, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan. Electronic address: kozo.tanaka.d2@tohoku.ac.jp.
2
Division of Experimental Pathology, Cancer Institute, Japanese Foundation for Cancer Research, Ariake 3-8-31, Koto-ku, Tokyo 135-8550, Japan. Electronic address: thirota@jfcr.or.jp.

Abstract

Most cancer cells are aneuploid, containing abnormal numbers of chromosomes, mainly caused by elevated levels of chromosome missegregation, known as chromosomal instability (CIN). These well-recognized, but poorly understood, features of cancers have recently been studied extensively, unraveling causal relationships between CIN and cancer. Here we review recent findings regarding how CIN and aneuploidy occur, how they affect cellular functions, how cells respond to them, and their relevance to diseases, especially cancer. Aneuploid cells are under various kinds of stresses that result in reduced cellular fitness. Nevertheless, genetic heterogeneity derived from CIN allows the selection of cells better adapted to their environment, which supposedly facilitates generation and progression of cancer. We also discuss how we can exploit the properties of cancer cells exhibiting CIN for effective cancer therapy.

KEYWORDS:

Aneuploidy; Cancer; Chromosomal instability; Chromosome segregation; Kinetochore; Mitosis

PMID:
27345585
DOI:
10.1016/j.bbcan.2016.06.002
[Indexed for MEDLINE]

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