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Biomarkers. 2017 Feb;22(1):19-27. doi: 10.1080/1354750X.2016.1201538. Epub 2016 Aug 5.

Bile: miRNA pattern and protein-based biomarkers may predict acute cellular rejection after liver transplantation.

Author information

1
a General, Visceral and Transplantation Surgery, Experimental Surgery and Regenerative Medicine , Charité - Universitätsmedizin Berlin , Campus Virchow Klinikum , Berlin , Germany.
2
b Department of Visceral, Transplantation, Thoracic, and Vascular Surgery , Universitätsklinikum Leipzig , Leipzig , Germany.

Abstract

CONTEXT:

Bile rather than blood depicts the local inflammation in the liver and may improve prediction and diagnosis of acute cellular rejection (ACR) after liver transplantation (OLT).

METHODS:

Secretome and miRNAs were analyzed during the first two weeks and on clinical suspicion of ACR in the bile of 45 OLT recipients.

RESULTS:

Levels of CD44, CXCL9, miR-122, miR-133a, miR-148a and miR-194 were significantly higher in bile of patients who developed ACR within the first 6 months after OLT and during ACR.

CONCLUSION:

Analysis of secretome and miRNA in bile could improve our understanding of the local inflammatory process during rejection.

KEYWORDS:

Immunosuppression; personalized medicine; risk stratification

PMID:
27344923
DOI:
10.1080/1354750X.2016.1201538
[Indexed for MEDLINE]

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