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Maturitas. 2016 Nov;93:28-33. doi: 10.1016/j.maturitas.2016.06.002. Epub 2016 Jun 22.

Carnosine and the processes of ageing.

Author information

1
Aston Research Centre for Healthy Ageing (ARCHA), Aston University, Birmingham B4 7ET, UK. Electronic address: alanandjill@lineone.net.
2
Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Melbourne, Australia.
3
Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Melbourne, Australia; Diabetes and Vascular Medicine Unit, Monash Health, Melbourne, Australia. Electronic address: barbora.decourten@monash.edu.

Abstract

The causes of ageing are usually regarded as multifactorial; thus effective regulation might be achieved by intervention at multiple sites. It has been suggested that the endogenous dipeptide carnosine, also available as a food supplement, possesses anti-ageing activity and may achieve its reported age-alleviating effects via a number of mechanisms. Carnosine's possible anti-ageing mechanisms are therefore discussed; the evidence suggests that inhibition of the mechanistic target of rapamycin and carbonyl scavenging may be involved.

KEYWORDS:

Advanced glycation end products; Ageing; Carnosine; Inflammation; Oxidative stress; Signalling pathways

PMID:
27344459
DOI:
10.1016/j.maturitas.2016.06.002
[Indexed for MEDLINE]

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