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J Pediatr. 2016 Sep;176:62-68.e4. doi: 10.1016/j.jpeds.2016.05.070. Epub 2016 Jun 22.

Growth Outcomes of Preterm Infants Exposed to Different Oxygen Saturation Target Ranges from Birth.

Collaborators (186)

Das A, Gantz M, Jobe AH, Caplan MS, Fanaroff AA, Wilson-Costello DE, Siner BS, Zadell A, DiFiore J, Bhola M, Friedman HG, Yalcinkaya G, Donovan EF, Narendran V, Yolton K, Bridges K, Alexander B, Grisby C, Mersmann MW, Mincey HL, Hessling J, Gratton TL, Goldberg RN, Goldstein RF, Ashley P, Auten KJ, Fisher KA, Foy KA, Freedman SF, Gustafson KE, Lohmeyer MB, Malcolm WF, Wallace DK, Stoll BJ, Adams-Chapman I, Buchter S, Carlton DP, Carter S, Fritz S, Hale EC, Hutchinson AK, LaRossa MM, Smikle GV, Archer SW, Dusick AM, Lemons JA, Myers GJ, Wilson LD, Hamer F, Cook AB, Herron DE, Lytle C, Minnich HM, Berberich MA, Blaisdell CJ, Gail DB, Kiley JP, Poole WK, Newman JE, Hastings BK, O'Donnell Auman J, Huitema CP, Pickett JW 2nd, Wallace D, Zaterka-Baxter KM, Stevenson DK, Hintz SR, Ball MB, Bentley B, Bruno EF, Davis AS, DeAnda ME, DeBattista AM, Huffman LC, Kohn JG, Proud MS, Pyle RP, St John NH, Weiss HE, Fiascone JM, McGowan EC, Furey A, MacKinnon BL, Nylen E, Brussa A, Sibley C, Ambalavanan N, Peralta-Carcelen M, Collins MV, Cosby SS, Phillips VA, Bailey KJ, Biasini FJ, Hopkins M, Johnston KC, Krzywanski S, Nelson KG, Patterson CS, Rector RV, Rodriguez L, Soong A, Whitley S, York S, Widness JA, Acarregui MJ, Klein JM, Colaizy TT, Johnson KJ, Eastman DL, Bauer CR, Everett-Thomas R, Calejo M, Diaz AN, Frade Eguaras SM, Garcia A, Hamlin-Smith K, Berkowits MH, Hiriart-Fajardo S, Pierre H, Rigaud A, Stroerger A, Ohls RK, Fuller J, Rohr J, Lacy CB, Lowe J, Montman R, Brion L, Rosenfeld CR, Salhab WA, Heyne RJ, Adams SS, Allen J, Chen L, Grau L, Guzman A, Hensley G, Heyne ET, Hickman J, Lepps MH, Madden LA, Miller NA, Morgan JS, Solis A, Torres LE, Boatman CT, Vasil DM, Kennedy KA, Tyson JE, Akpa EG, Alaniz NI, Dieterich S, Evans PW, Green C, Harris BF, Jiminez M, Lis AE, Martin K, Martin S, McDavid GE, Morris BH, Poundstone ML, Reddoch S, Siddiki S, Simmons MC, Pierce Tate PL, Wright SL, Sood BG, Pappas A, Bara R, Billian E, Goldston LA, Johnson M, Bhandari V, Jacobs HC, Cervone P, Gettner P, Konstantino M, Poulsen J, Taft J, Butler CG, Close N, Gilliam W, Greisman S, Romano E, Williams J.

Author information

1
University of Miami Miller School of Medicine, Miami, FL. Electronic address: cnavarrete@med.miami.edu.
2
Social, Statistical and Environmental Sciences Unit, RTI International, Research Triangle Park, NC.
3
Division of Neonatology, University of Alabama at Birmingham, Birmingham, AL.
4
Department of Pediatrics, Rainbow Babies & Children's Hospital, Case Western Reserve University, Cleveland, OH.
5
Division of Neonatology, University of California San Diego, San Diego, CA.
6
Social, Statistical and Environmental Sciences Unit, RTI International, Rockville, MD.
7
Department of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH.
8
Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, Atlanta, GA.
9
Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN.
10
Department of Pediatrics, Wayne State University, Detroit, MI.
11
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX.
12
Department of Pediatrics, University of Texas Medical School at Houston, Houston, TX.
13
Division of Newborn Medicine, Department of Pediatrics, Floating Hospital for Children, Tufts Medical Center, Boston, MA.
14
Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine and Lucile Packard Children's Hospital, Palo Alto, CA.
15
Department of Pediatrics, Duke University, Durham, NC.
16
Department of Pediatrics, Yale University School of Medicine, New Haven, CT.
17
Department of Pediatrics, University of Iowa, Iowa City, IA.
18
University of New Mexico Health Sciences Center, Albuquerque, NM.
19
Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD.
20
University of Miami Miller School of Medicine, Miami, FL.

Abstract

OBJECTIVE:

To test whether infants randomized to a lower oxygen saturation (peripheral capillary oxygen saturation [SpO2]) target range while on supplemental oxygen from birth will have better growth velocity from birth to 36 weeks postmenstrual age (PMA) and less growth failure at 36 weeks PMA and 18-22 months corrected age.

STUDY DESIGN:

We evaluated a subgroup of 810 preterm infants from the Surfactant, Positive Pressure, and Oxygenation Randomized Trial, randomized at birth to lower (85%-89%, n = 402, PMA 26 ± 1 weeks, birth weight 839 ± 186 g) or higher (91%-95%, n = 408, PMA 26 ± 1 weeks, birth weight 840 ± 191 g) SpO2 target ranges. Anthropometric measures were obtained at birth, postnatal days 7, 14, 21, and 28; then at 32 and 36 weeks PMA; and 18-22 months corrected age. Growth velocities were estimated with the exponential method and analyzed with linear mixed models. Poor growth outcome, defined as weight <10th percentile at 36 weeks PMA and 18-22 months corrected age, was compared across the 2 treatment groups by the use of robust Poisson regression.

RESULTS:

Growth outcomes including growth at 36 weeks PMA and 18-22 months corrected age, as well as growth velocity were similar in the lower and higher SpO2 target groups.

CONCLUSION:

Targeting different oxygen saturation ranges between 85% and 95% from birth did not impact growth velocity or reduce growth failure in preterm infants.

KEYWORDS:

ELBW growth; oxygen saturation target

PMID:
27344218
PMCID:
PMC5327617
DOI:
10.1016/j.jpeds.2016.05.070
[Indexed for MEDLINE]
Free PMC Article

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