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Am J Transplant. 2017 Feb;17(2):328-335. doi: 10.1111/ajt.13940. Epub 2016 Jul 25.

The Role of Neutrophils in Transplanted Organs.

Author information

1
Department of Surgery, Washington University School of Medicine, St. Louis, MO.
2
Department of Medical - Surgical Science and Translational Medicine, Sapienza University of Rome, Italy.
3
Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO.
#
Contributed equally

Abstract

Neutrophils are often viewed as nonspecialized effector cells whose presence is a simple indicator of tissue inflammation. There is new evidence that neutrophils exist in subsets and have specialized effector functions that include extracellular trap generation and the stimulation of angiogenesis. The application of intravital imaging to transplanted organs has revealed novel requirements for neutrophil trafficking into graft tissue and has illuminated direct interactions between neutrophils and other leukocytes that promote alloimmunity. Paradoxically, retaining some neutrophilia may be important to induce or maintain tolerance. Neutrophils can stimulate anti-inflammatory signals in other phagocytes and release molecules that inhibit T cell activation. In this article, we will review the available evidence of how neutrophils regulate acute and chronic inflammation in transplanted organs and discuss the possibility of targeting these cells to promote tolerance.

KEYWORDS:

basic (laboratory) research/science; immune regulation; immunobiology; innate immunity; organ transplantation in general; rejection; tolerance: clinical; tolerance: mechanisms

PMID:
27344051
PMCID:
PMC5183560
DOI:
10.1111/ajt.13940
[Indexed for MEDLINE]
Free PMC Article

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