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Curr Opin Immunol. 2016 Aug;41:62-67. doi: 10.1016/j.coi.2016.06.001. Epub 2016 Jun 22.

Antibody-guided vaccine design: identification of protective epitopes.

Author information

1
Institute for Research in Biomedicine, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland; Institute of Microbiology, ETH Zürich, Vladimir-Prelog-Weg 1, 8093 Zürich, Switzerland. Electronic address: lanzavecchia@irb.usi.ch.
2
Institute for Research in Biomedicine, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland.
3
Humabs BioMed, Via Mirasole 1, 6500 Bellinzona, Switzerland.

Abstract

In the last decade, progress in the analysis of the human immune response and in the isolation of human monoclonal antibodies have provided an innovative approach to the identification of protective antigens which are the basis for the design of vaccines capable of eliciting effective B-cell immunity. In this review we illustrate, with relevant examples, the power of this approach that can rapidly lead to the identification of protective antigens in complex pathogens, such as human cytomegalovirus and Plasmodium falciparum, and of conserved sites in highly variable antigens, such as influenza hemagglutinin and HIV-1 Env. We will also discuss how the genealogical analysis of antigen-stimulated B cell clones provides the basis to delineate the best suitable prime-boost vaccination strategy for the induction of broadly neutralizing antibodies.

PMID:
27343848
DOI:
10.1016/j.coi.2016.06.001
[Indexed for MEDLINE]
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