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J Mol Biol. 2016 Aug 14;428(16):3282-3294. doi: 10.1016/j.jmb.2016.05.028. Epub 2016 Jun 23.

O-GlcNAcylation in Cancer Biology: Linking Metabolism and Signaling.

Author information

1
Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA 19102, USA.
2
Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA 19102, USA. Electronic address: Mauricio.Reginato@drexelmed.edu.

Abstract

The hexosamine biosynthetic pathway (HBP) is highly dependent on multiple metabolic nutrients including glucose, glutamine, and acetyl-CoA. Increased flux through HBP leads to elevated post-translational addition of β-D-N-acetylglucosamine sugars to nuclear and cytoplasmic proteins. Increased total O-GlcNAcylation is emerging as a general characteristic of cancer cells, and recent studies suggest that O-GlcNAcylation is a central communicator of nutritional status to control key signaling and metabolic pathways that regulate multiple cancer cell phenotypes. This review summarizes our current understanding of changes of O-GlcNAc cycling enzymes in cancer, the role of O-GlcNAcylation in tumorigenesis, and the current challenges in targeting this pathway therapeutically.

KEYWORDS:

O-GlcNAcylation; OGT; cancer; glycosylation; signaling

PMID:
27343361
PMCID:
PMC4983259
DOI:
10.1016/j.jmb.2016.05.028
[Indexed for MEDLINE]
Free PMC Article

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