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Int J Mol Sci. 2016 Jun 22;17(6). pii: E989. doi: 10.3390/ijms17060989.

The Obesity-Breast Cancer Conundrum: An Analysis of the Issues.

Author information

1
Cancer Prevention Laboratory, Colorado State University, Fort Collins, CO 80523, USA. shawna.matthews@ucdenver.edu.
2
Cancer Prevention Laboratory, Colorado State University, Fort Collins, CO 80523, USA. henry.thompson@colostate.edu.

Abstract

Breast cancer develops over a timeframe of 2-3 decades prior to clinical detection. Given this prolonged latency, it is somewhat unexpected from a biological perspective that obesity has no effect or reduces the risk for breast cancer in premenopausal women yet increases the risk for breast cancer in postmenopausal women. This conundrum is particularly striking in light of the generally negative effects of obesity on breast cancer outcomes, including larger tumor size at diagnosis and poorer prognosis in both pre- and postmenopausal women. This review and analysis identifies factors that may contribute to this apparent conundrum, issues that merit further investigation, and characteristics of preclinical models for breast cancer and obesity that should be considered if animal models are used to deconstruct the conundrum.

KEYWORDS:

breast cancer; mechanisms; obesity; preclinical models

PMID:
27338371
PMCID:
PMC4926517
DOI:
10.3390/ijms17060989
[Indexed for MEDLINE]
Free PMC Article

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