Format

Send to

Choose Destination
Angew Chem Int Ed Engl. 2016 Jul 18;55(30):8502-27. doi: 10.1002/anie.201601524. Epub 2016 Jun 23.

Mechanisms of DNA Repair by Photolyase and Excision Nuclease (Nobel Lecture).

Author information

1
Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA. Aziz_Sancar@med.unc.edu.

Abstract

Ultraviolet light damages DNA by converting two adjacent thymines into a thymine dimer which is potentially mutagenic, carcinogenic, or lethal to the organism. This damage is repaired by photolyase and the nucleotide excision repair system in E. coli by nucleotide excision repair in humans. The work leading to these results is presented by Aziz Sancar in his Nobel Lecture.

KEYWORDS:

Maxicell method; circadian clock; cryptochrome; nucleotide excision repair; photoreactivation

PMID:
27337655
DOI:
10.1002/anie.201601524
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center