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Glob Pediatr Health. 2014 Oct 9;1:2333794X14553625. doi: 10.1177/2333794X14553625. eCollection 2014.

Improving the Rate of Sufficient Sweat Collected in Infants Referred for Sweat Testing in Michigan.

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Children's Hospital of Michigan Cystic Fibrosis Center, Detroit, MI, USA.
Michigan Department of Community Health, Lansing, MI, USA.
Michigan State University Cystic Fibrosis Center, East Lansing, MI, USA.
Helen DeVos Children's Hospital Cystic Fibrosis Center, Grand Rapids, MI, USA.
University of Michigan Cystic Fibrosis Center, Ann Arbor, MI, USA.



Sweat collected for testing should have quantity not sufficient (QNS) rate of ≤10% in babies ≤3 months of age. Michigan (MI) cystic fibrosis (CF) centers' QNS rates were 12% to 25% in 2009. This project was initiated to reduce sweat QNS rates in MI. Methods/Steps. (a) Each center's sweat testing procedures were reviewed by a consultant. (b) Each center received a report with recommendations to improve QNS rates. (c) Technicians visited other participating centers to observe their procedures.


A total of 778 infants were identified as positive via CF newborn screening over a 2-year period. The mean age at time of sweat test was 23.2 days (SD ± 13.0 days). The overall QNS percent decreased from 14.4% to 9.5% (P = .04) during the study.


This project and teamwork approach led to a decrease of sweat test QNS rates, opportunities to solve a common problem, and improved quality of care.


general pediatrics; genetics; infectious diseases; neonatology; pulmonology

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