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Int J Psychiatry Clin Pract. 2016 Sep;20(3):165-9. doi: 10.1080/13651501.2016.1197274. Epub 2016 Jun 23.

Prolactin levels in drug-naïve patients with schizophrenia and other psychotic disorders.

Author information

1
a Psychiatric Clinic, Medical School, University of Ioannina (UOI) , Ioannina , Greece ;
2
b Department of Endocrinology , Medical School, University of Ioannina (UOI) , Ioannina , Greece ;
3
c Department of Computer Engineering, School of Applied Technology , Technological Educational Institute of Epirus (TEIEP) , Arta , Greece ;
4
d Rheumatology Clinic, Department of Internal Medicine , Medical School, University of Ioannina (UOI) , Ioannina , Greece.

Abstract

OBJECTIVE:

Hyperprolactinaemia as a side effect of dopamine receptor blockers is common in patients with schizophrenia and other psychotic disorders and may lead to amenorrhoea, galactorrhoea, hypogonadism, subfertility and osteoporosis. The aim of our study was to determine whether hyperprolactinaemia occurs also in patients with schizophrenia and other psychotic disorders prior to any antipsychotic treatment.

METHODS:

Serum prolactin, thyroid-stimulating hormone (TSH), triiodothyronine (T3), free tetraiodothyronine (FT4) and cortisol levels were measured in 40 newly diagnosed, drug naïve, patients with schizophrenia and other psychotic disorders and in 40 age and gender matched healthy subjects.

RESULTS:

The median prolactin value was 12.5 ng/ml (range: 2-38 ng/ml) for patients and 8.6 ng/ml (range: 4-17.6 ng/ml) for healthy subjects (p = 0.011). Patients had lower levels of T3 compared to healthy controls (mean: 1.08 ng/ml, SD: 0.16 vs. 1.18 ng/ml, 0.18, respectively; p = 0.008). Serum TSH, FT4 and cortisol levels were similar between the two groups. Multiple regression analysis revealed that the difference in serum prolactin values was independent of thyroid function (TSH, FT4, T3) and serum cortisol levels.

CONCLUSIONS:

A higher serum prolactin level was found in drug naïve, newly diagnosed patients with schizophrenia and other psychotic disorders compared to healthy controls, prior to starting any antipsychotic treatment.

KEYWORDS:

Drug-naïve patient; first episode; hyperprolactinaemia; schizophrenia and other psychotic disorders

PMID:
27334805
DOI:
10.1080/13651501.2016.1197274
[Indexed for MEDLINE]

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