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J Chem Neuroanat. 2017 Oct;83-84:41-49. doi: 10.1016/j.jchemneu.2016.06.001. Epub 2016 Jun 19.

Alpha-synuclein modulates dopamine neurotransmission.

Author information

1
University of Florida, Department of Neuroscience and Department of Psychiatry Gainesville, FL 32611.
2
University of Florida, Department of Neuroscience and Department of Psychiatry Gainesville, FL 32611. Electronic address: Habibeh@ufl.edu.

Abstract

Alpha-synuclein is a small, highly charged protein encoded by the synuclein or SNCA gene that is predominantly expressed in central nervous system neurons. Although its physiological function remains enigmatic, alpha-synuclein is implicated in movement disorders such as Parkinson's disease, multiple system atrophy, and in neurodegenerative diseases such as Dementia with Lewy bodies. Here we have focused on reviewing the existing literature pertaining to wild-type alpha-synuclein structure, its properties, and its potential involvement in regulation of dopamine neurotransmission.

PMID:
27334403
PMCID:
PMC5167661
DOI:
10.1016/j.jchemneu.2016.06.001
[Indexed for MEDLINE]
Free PMC Article

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