Format

Send to

Choose Destination
Am J Transplant. 2017 Jan;17(1):140-150. doi: 10.1111/ajt.13929. Epub 2016 Jul 22.

Banff Histopathological Consensus Criteria for Preimplantation Kidney Biopsies.

Author information

1
Department of Pathology & Immunology, Washington University School of Medicine, St Louis, MO.
2
Nephropath, Little Rock, AR.
3
Piedmont Hospital, Atlanta, GA.
4
Department of Pathology & Internal Medicine, Johns Hopkins University Hospital, Baltimore, MD.
5
Emory University Hospital, Atlanta, GA.
6
IKEM, Prague, Czech Republic.
7
Transplantation Institute, Medical University of Warsaw, Warsaw, Poland.
8
University of Sao Paulo, Renal Transplant Service, Sao Paulo, Brazil.
9
INCUCAI (Argentinian Nacional Institute for procurement and Implants) and CUCAIBA (Buenos Aires Inst of procurement and implants), Buenos Aires, Argentina.
10
Mayo Clinic, Scottsdale, AZ.
11
Department of Pathology, University of Alberta, Alberta, Canada.
12
Cedars-Sinai Medical Center, Department of Pathology & Lab Medicine, Los Angeles, CA.
13
Department of Pathology, Cornell University, New York, NY.
14
Santa Casa de Misericordia de Porto Alegre Hospital and Universidade Federal de Ciências da Saúde de Porto Alegre, Rio Grande do Sul, Brazil.
15
Department of Pharmacy, Barnes-Jewish Hospital, Saint Louis, MO.
16
Department of Pathology, University of Pittsburgh, Thomas E Starzl Transplant Institute, Pittsburgh, PA.

Abstract

The Banff working group on preimplantation biopsy was established to develop consensus criteria (best practice guidelines) for the interpretation of preimplantation kidney biopsies. Digitally scanned slides were used (i) to evaluate interobserver variability of histopathologic findings, comparing frozen sections with formalin-fixed, paraffin-embedded tissue of wedge and needle core biopsies, and (ii) to correlate consensus histopathologic findings with graft outcome in a cohort of biopsies from international medical centers. Intraclass correlations (ICCs) and univariable and multivariable statistical analyses were performed. Good to fair reproducibility was observed in semiquantitative scores for percentage of glomerulosclerosis, arterial intimal fibrosis and interstitial fibrosis on frozen wedge biopsies. Evaluation of frozen wedge and core biopsies was comparable for number of glomeruli, but needle biopsies showed worse ICCs for glomerulosclerosis, interstitial fibrosis and tubular atrophy. A consensus evaluation form is provided to help standardize the reporting of histopathologic lesions in donor biopsies. It should be recognized that histologic parameters may not correlate with graft outcome in studies based on organs deemed to be acceptable after careful clinical assessment. Significant limitations remain in the assessment of implantation biopsies.

KEYWORDS:

biopsy; clinical research/practice; donors and donation: deceased; kidney (allograft) function/dysfunction; kidney failure/injury; pathology/histopathology

PMID:
27333454
DOI:
10.1111/ajt.13929
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center