Format

Send to

Choose Destination
Allergy. 2016 Dec;71(12):1701-1711. doi: 10.1111/all.12964. Epub 2016 Jul 27.

Mould-sensitized adults have lower Th2 cytokines and a higher prevalence of asthma than those sensitized to other aeroallergens.

Author information

1
Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Vic., Australia.
2
Murdoch Children's Research Institute, Royal Children's Hospital Melbourne, Melbourne, Vic., Australia.
3
Department of Paediatrics, The University of Melbourne, Melbourne, Vic., Australia.
4
Biostatistics Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Vic., Australia.
5
Gold Coast Hospital, Southport, Qld, Australia.
6
Bond University, Varsity Lakes, Qld, Australia.
7
Department of Pathology, University of Melbourne, Melbourne, Vic., Australia.
8
University of Queensland, Brisbane, Qld, Australia.
9
Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Vic., Australia.
10
Menzies Research Institute, Hobart, Tas., Australia.

Abstract

BACKGROUND:

Evidence suggests that specific allergen sensitizations are associated with different allergic diseases which may reflect different underlying immune profiles. We aimed to examine the cytokine profiles of individuals sensitized to eight common aeroallergens.

METHODS:

We used data from the Tasmanian Longitudinal Health Study a population-based cohort study of 45-year-olds. Serum cytokines (IL-4, IL-5, IL-6, IL-8, IL-10, TNF-α) were measured in 1157 subjects using the LINCOplex assays. Participants underwent skin prick testing for house dust mite, cat, grasses and moulds. Multivariable linear regression was used to compare serum cytokine levels between sensitized and nonatopic subjects.

RESULTS:

The prevalence of allergic sensitization to any aeroallergen was 51% (95% CI 47-54). Being sensitized to any aeroallergen was strongly associated with current asthma (OR = 3.7, 95% CI 2.6-5.3), and being sensitized to any moulds was associated with a very high risk of current asthma (OR = 6.40, 95% CI 4.06-10.1). The geometric mean (GM) levels of Th2 cytokines (IL-4, IL-5 and IL-6) for adults sensitized to Cladosporium were significantly lower than the levels for nonatopic individuals (IL-4 ratio of GMs = 0.25, 95% CI 0.10-0.62, P = 0.003; IL-5 GM = 0.55, 95% CI 0.30-0.99, P = 0.05; and IL-6 GM = 0.50, 95% CI 0.24-1.07, P = 0.07). Individuals sensitized to other aeroallergens all showed elevated Th2 cytokine levels.

CONCLUSION:

Our study is the first large population-based study to demonstrate reduced Th2 cytokines levels in people sensitized to mould. Underlying biological mechanisms driving allergic inflammatory responses in adults sensitized to moulds may differ from those sensitized to other aeroallergens. These findings suggest that it may be necessary to tailor treatments in individuals sensitized to moulds compared with other aeroallergens in order to optimize outcomes.

KEYWORDS:

asthma; cytokines; mould; skin prick tests

PMID:
27333124
DOI:
10.1111/all.12964
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center