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Data Brief. 2016 May 18;8:211-9. doi: 10.1016/j.dib.2016.04.069. eCollection 2016 Sep.

Data from acellular human heart matrix.

Author information

1
Department of Cardiology, Hospital General Universitario Gregorio Marañón, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Gregorio Marañon (IiSGM), Madrid, Spain; Bioartifical Organs Laboratory, Instituto de Investigación Sanitaria Gregorio Marañon (IiSGM), Madrid, Spain; Hospital Universitario de Salamanca, IBSAL, Salamanca, Spain.
2
Bioartifical Organs Laboratory, Instituto de Investigación Sanitaria Gregorio Marañon (IiSGM), Madrid, Spain; Cell Production Unit, Instituto de Investigación Sanitaria Gregorio Marañon (IiSGM), Madrid, Spain.
3
Department of Cardiology, Hospital General Universitario Gregorio Marañón, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Gregorio Marañon (IiSGM), Madrid, Spain; Bioartifical Organs Laboratory, Instituto de Investigación Sanitaria Gregorio Marañon (IiSGM), Madrid, Spain.
4
Bioartifical Organs Laboratory, Instituto de Investigación Sanitaria Gregorio Marañon (IiSGM), Madrid, Spain.
5
Department of Cardiovascular Development and Repair, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Spain.
6
Department of Cardiac Surgery, Hospital General Universitario Gregorio Marañón. Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Gregorio Marañon (IiSGM), Madrid, Spain.
7
Department of Pathology, Hospital General Universitario Gregorio Marañón, Universidad Complutense de Madrid. Instituto de Investigación Sanitaria Gregorio Marañon (IiSGM), Madrid, Spain.
8
Photography & Comunication, Hospital General Universitario Gregorio Marañón, Universidad Complutense de Madrid. Instituto de Investigación Sanitaria Gregorio Marañon (IiSGM), Madrid, Spain.
9
Center for Cardiovascular Repair, University of Minnesota, Minneapolis, USA.
10
Department of Cardiology, Hospital General Universitario Gregorio Marañón, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Gregorio Marañon (IiSGM), Madrid, Spain.
11
Regenerative Medicine Research, Texas Heart Institute, Houston, USA.

Abstract

Perfusion decellularization of cadaveric hearts removes cells and generates a cell-free extracellular matrix scaffold containing acellular vascular conduits, which are theoretically sufficient to perfuse and support tissue-engineered heart constructs. This article contains additional data of our experience decellularizing and testing structural integrity and composition of a large series of human hearts, "Acellular human heart matrix: a critical step toward whole heat grafts" (Sanchez et al., 2015) [1]. Here we provide the information about the heart decellularization technique, the valve competence evaluation of the decellularized scaffolds, the integrity evaluation of epicardial and myocardial coronary circulation, the pressure volume measurements, the primers used to assess cardiac muscle gene expression and, the characteristics of donors, donor hearts, scaffolds and perfusion decellularization process.

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