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J Lasers Med Sci. 2016 Spring;7(2):120-5. doi: 10.15171/jlms.2016.20. Epub 2016 Mar 27.

Effects of 3 Hz and 60 Hz Extremely Low Frequency Electromagnetic Fields on Anxiety-Like Behaviors, Memory Retention of Passive Avoidance and Electrophysiological Properties of Male Rats.

Author information

1
Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2
Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3
Department of Pharmacology, Tehran University of Medical Sciences, Tehran, Iran.
4
Department of Physiology, School of Medical Sciences, Tarbiat Modarres University, Tehran, Iran.
5
Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
6
Cancer Research Center and Department of Medical Physics, Semnan University of Medical Sciences, Semnan, Iran.

Abstract

INTRODUCTION:

The effects of electromagnetic fields on biological organisms have been a controversial and also interesting debate over the past few decades, despite the wide range of investigations, many aspects of extremely low frequency electromagnetic fields (ELF/EMFs) effects including mechanism of their interaction with live organisms and also their possible biological applications still remain ambiguous. In the present study, we investigated whether the exposures of ELF/EMF with frequencies of 3 Hz and 60 Hz can affect the memory, anxiety like behaviors, electrophysiological properties and brain's proteome in rats.

METHODS:

Male rats were exposed to 3 Hz and 60 Hz ELF/EMFs in a protocol consisting of 2 cycles of 2 h/day exposure for 4 days separated with a 2-day interval. Short term memory and anxiety like behaviors were assessed immediately, 1 and 2 weeks after the exposures. Effects of short term exposure were also assessed using electrophysiological approach immediately after 2 hours exposure.

RESULTS:

Behavioral test revealed that immediately after the end of exposures, locomotor activity of both 3 Hz and 60 Hz exposed groups significantly decreased compared to sham group. This exposure protocol had no effect on anxiety like behavior during the 2 weeks after the treatment and also on short term memory. A significant reduction in firing rate of locus coeruleus (LC) was found after 2 hours of both 3 Hz and 60 Hz exposures. Proteome analysis also revealed global changes in whole brain proteome after treatment.

CONCLUSION:

Here, some evidence regarding the fact that such exposures can alter locomotor activity and neurons firing rate in male rats were presented.

KEYWORDS:

ELF/EMFs; Locomotion; Locus Coeruleus; Memory

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