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Emerg Microbes Infect. 2016 Jun 22;5:e62. doi: 10.1038/emi.2016.62.

The emergence and outbreak of multidrug-resistant typhoid fever in China.

Yan M1,2, Li X3, Liao Q4, Li F3, Zhang J4, Kan B1,2.

Author information

1
Department of Diarrheal Disease, State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
2
Department of Diarrheal Disease, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, Zhejiang 310000, China.
3
Department of Diarrheal Disease, Xinjiang Center for Disease Control and Prevention, Urumqi, Xinjiang 830000, China.
4
Department of Diarrheal Disease, Chinese Center for Disease Control and Prevention, Beijing 102206, China.

Abstract

Typhoid fever remains a severe public health problem in developing countries. The emergence of resistant typhoid, particularly multidrug-resistant typhoid infections, highlights the necessity of monitoring the resistance characteristics of this invasive pathogen. In this study, we report a typhoid fever outbreak caused by multidrug-resistant Salmonella enterica serovar Typhi strains with an ACSSxtT pattern. Resistance genes conferring these phenotypes were harbored by a large conjugative plasmid, which increases the threat of Salmonella Typhi and thus requires close surveillance for dissemination of strains containing such genes.

PMID:
27329848
PMCID:
PMC4932652
DOI:
10.1038/emi.2016.62
[Indexed for MEDLINE]
Free PMC Article

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