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Pediatrics. 2016 Jul;138(1). pii: e20154126. doi: 10.1542/peds.2015-4126. Epub 2016 Jun 21.

A Practical Approach to the Diagnosis and Treatment of Vitiligo in Children.

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Department of Dermatology, Henri Mondor Hospital and EpiDermE, Université Paris-Est Créteil Val-de-Marne, Créteil, France; and
Department of Dermatology and Pediatrics, Mount Sinai St. Luke's-Roosevelt and Beth Israel Medical Centers, New York, New York.


Vitiligo is a common inflammatory skin disease with a worldwide prevalence of 0.5% to 2.0% of the population. In the pediatric population, the exact prevalence of vitiligo is unknown, although many studies state that most cases of vitiligo are acquired early in life. The disease is disfiguring, with a major psychological impact on children and their parents. Half of vitiligo cases have a childhood onset, needing thus a treatment approach that will minimize treatment side effects while avoiding psychological impacts. Management of vitiligo should take into account several factors, including extension, psychological impact, and possible associations with other autoimmune diseases. This review discusses the epidemiology of vitiligo and outlines the various clinical presentations associated with the disorder and their differential diagnosis. In addition, the pathophysiology and genetic determinants, the psychological impact of vitiligo, and management strategies are reviewed.

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