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Sci Rep. 2016 Jun 22;6:28556. doi: 10.1038/srep28556.

Attenuated viral hepatitis in Trem1-/- mice is associated with reduced inflammatory activity of neutrophils.

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University Medical Centre Hamburg-Eppendorf, Department of Medicine I, 20246 Hamburg, Germany.
University Medical Centre Hamburg-Eppendorf, Institute of Medical Microbiology, Virology and Hygiene, 20246 Hamburg, Germany.
University Medical Centre Hamburg-Eppendorf, Institute of Pathology, 20246 Hamburg, Germany.
University Medical Centre Hamburg-Eppendorf, Institute of Biochemistry and Molecular Cell Biology, 20246 Hamburg, Germany.


TREM1 (Triggering Receptor Expressed on Myeloid Cells 1) is a pro-inflammatory receptor expressed by phagocytes, which can also be released as a soluble molecule (sTREM1). The roles of TREM1 and sTREM1 in liver infection and inflammation are not clear. Here we show that patients with hepatitis B virus (HBV) or hepatitis C virus (HCV) infection manifest elevated serum levels of sTREM1. In mice, experimental viral hepatitis induced by infection with Lymphocytic Choriomeningitis Virus (LCMV)-WE was likewise associated with increased sTREM1 in serum and urine, and with increased TREM1 and its associated adapter molecule DAP12 in the liver. Trem1-/- mice showed accelerated clearance of LCMV-WE and manifested attenuated liver inflammation and injury. TREM1 expression in the liver of wild-type mice was mostly confined to infiltrating neutrophils, which responded to LCMV by secretion of CCL2 and TNF-α, and release of sTREM1. Accordingly, the production of CCL2 and TNF-α was decreased in the livers of LCMV-infected Trem1-/- mice, as compared to LCMV-infected wildtype mice. These findings indicate that TREM1 plays a role in viral hepatitis, in which it seems to aggravate the immunopathology associated with viral clearance, mainly by increasing the inflammatory activity of neutrophils.

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