Send to

Choose Destination
Free Radic Res. 2016;50(11):1165-1172. Epub 2016 Aug 25.

Relationship between serum arginase I and l-arginine or exhaled nitric oxide in asthma.

Author information

a Department of Public Health , Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama , Japan.
b Division of Respiratory Diseases, Department of Medicine , Kawasaki Medical School , Okayama , Japan.
c Second Department of Internal Medicine , Nagasaki University School of Medicine , Nagasaki , Japan.
d Department of Molecular Pathology , Memorial Sloan-Kettering Cancer Center , New York , NY , USA.
e Respiratory Medicine, National Hospital Organization Nanao Hospital , Nanao , Japan.
f Department of Environmental and Preventive Medicine , Graduate School of Medical Science, Kanazawa University , Kanazawa , Japan.


The relationship between serum arginase I and serum l-arginine or fractional exhaled nitric oxide (FENO) was evaluated cross-sectionally in asthmatic patients. No sex difference was observed in the serum mean levels of arginase I and l-arginine or FENO. Arginase I and FENO were higher in patients 60 or younger years than in those over 60 years. Asthmatic patients were divided into three groups: no steroid therapy, inhalation steroid therapy, and oral steroid therapy. Arginase I, FENO and high-sensitivity-C-reactive protein (hs-CRP) were significantly lower in the inhalation steroid therapy group than in the no steroid therapy group. Correlations were observed between arginase I and FENO, l-arginine, hs-CRP, WBC, and age, and also between FENO and IgE, WBC, and age. A logistic regression analysis revealed the positive association of arginase I with FENO, and the negative association of l-arginine. FENO was positively associated with arginase I and IgE. These results indicated that serum arginase I might influence serum levels of l-arginine and FENO, and that IgE might influence FENO in asthmatic patients.


Arginase I; clinical study; fractional exhaled nitric oxide (FENO); l-arginine

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center