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Sci Rep. 2016 Jun 22;6:28414. doi: 10.1038/srep28414.

Evolutionary features of thyroid cancer in patients with thyroidectomies from 2008 to 2013 in China.

Author information

1
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
2
Department of Children's Health care, Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, China.
3
Department of Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
4
Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
5
Thyroid Unit, Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, Brigham &Women's Hospital and Harvard Medical School, Boston, USA.

Abstract

To evaluate the characteristics of thyroid carcinoma over time, we carried out a retrospective study to illustrate the evolutionary features of thyroid carcinoma. All records of thyroidectomies from the First Affiliated Hospital of Nanjing Medical University from 2008 to 2013 were obtained focusing on pathological diagnosis, size, local lymph node metastasis (LNM) of the tumors. The thyroid cancer detection rate increased from 24.6% to 41.5% significantly (P < 0.05). Papillary thyroid carcinoma (PTC) remained to be the most common type counting 86.4% of all thyroid carcinomas. In all 1,704 PTCs, microPTC (mPTC) with maximum diameter less than or equal to 10 mm has become the dominant form taking up 56.5% of all PTCs in 2013 while only 43.1% in 2008. The mean maximum tumor size has decreased from 17.8 mm to 12.2 mm significantly (P < 0.05). However, the average age, female dominance, and local LNM remained similarly in the past six years. Logistic regression test showed that the determinants for local LNM were age, gender and tumor size. mPTC has become the most common form of thyroid carcinoma detected during thyroidectomies in China while other features of thyroid carcinoma remained similarly in the recent years.

PMID:
27328631
PMCID:
PMC4916471
DOI:
10.1038/srep28414
[Indexed for MEDLINE]
Free PMC Article

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