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Nat Immunol. 2016 Jun 21;17(7):790-4. doi: 10.1038/ni.3459.

The evolution of innate lymphoid cells.

Author information

1
Centre d'Immunologie de Marseille-Luminy, Aix-Marseille University UM2, Inserm, U1104, CNRS UMR7280, Marseille, France.
2
Hôpital de la Conception, Assistance Publique-Hôpitaux de Marseille, Marseille, France.
3
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
4
The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.
5
Department of Medical Biology, University of Melbourne, Parkville, Australia.

Abstract

Innate lymphoid cells (ILCs) are the most recently discovered group of immune cells. Understanding their biology poses many challenges. We discuss here the current knowledge on the appearance of ILC subsets during evolution and propose how the connection between ILCs and T cells contributes to the robustness of immunity and hence to the fitness of the hosts.

PMID:
27328009
PMCID:
PMC5287353
DOI:
10.1038/ni.3459
[Indexed for MEDLINE]
Free PMC Article

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