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J Gen Virol. 1989 Feb;70 ( Pt 2):467-72.

Destruction of lymphocytes by a virulent avian influenza A virus.

Author information

1
Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison 53706.

Abstract

Infection of chickens by a virulent avian influenza A virus, A/turkey/Ont/7732/66 (H5N9), was associated with a severe lymphopenia. High titres of infectious virus were found in lymphoid tissues early in infection and were accompanied by severe damage to the lymphocyte populations as demonstrated by histopathological examination. Non-lymphoid cell populations in these tissues were unaffected, as were other organs examined. The viral nucleoprotein was localized by immunoperoxidase staining to lymphocytes in affected tissues early in infection.

PMID:
2732695
DOI:
10.1099/0022-1317-70-2-467
[Indexed for MEDLINE]

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