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Curr Opin Immunol. 2016 Oct;42:76-82. doi: 10.1016/j.coi.2016.06.003. Epub 2016 Jun 18.

Toll-like receptor 2 in host defense against Mycobacterium tuberculosis: to be or not to be-that is the question.

Author information

1
Department of Medicine, Center for Emerging Pathogens, Rutgers, New Jersey Medical School, Newark, NJ, USA.
2
Department of Medicine, Center for Emerging Pathogens, Rutgers, New Jersey Medical School, Newark, NJ, USA. Electronic address: padmini.salgame@rutgers.edu.

Abstract

Toll-like receptor (TLR) 2 is expressed on immune cells and respiratory epithelial cells lining the lung. TLR2 is not critical for protection during acute Mycobacterium tuberculosis (Mtb) infection but it has a significant multi-faceted role in containing chronic infection. This review highlights the contribution of TLR2 to host protection, immune evasion by Mtb and immune regulation during chronic Mtb infection. The TLR2-triggered pro-inflammatory cytokines initiate protective mechanisms and limit Mtb replication while the immune evasion pathways counterattack anti-bacterial effector mechanisms. The immune regulation pathways that are activated dampen TLR2 signaling. The combinatorial effect of these functional responses is persistence of Mtb with minimal immunopathology.

PMID:
27326654
PMCID:
PMC5086274
DOI:
10.1016/j.coi.2016.06.003
[Indexed for MEDLINE]
Free PMC Article

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