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Food Funct. 2016 Jul 13;7(7):3017-30. doi: 10.1039/c6fo00335d.

The antiviral effects of acteoside and the underlying IFN-γ-inducing action.

Author information

1
Department of Pharmacy, Shenzhen Key Laboratory of Novel Natural Health Care Products, Innovation Platform for Natural Small Molecule Drugs, Engineering Laboratory of Shenzhen Natural Small Molecule Innovative Drugs, School of Medicine, College of Life Science, Shenzhen University, Shenzhen 518060, P. R. China. jzhanghappy@szu.edu.cn hezhendan@126.com and School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, P. R. China. zhanghj@hkbu.edu.hk.
2
Department of Pharmacy, Shenzhen Key Laboratory of Novel Natural Health Care Products, Innovation Platform for Natural Small Molecule Drugs, Engineering Laboratory of Shenzhen Natural Small Molecule Innovative Drugs, School of Medicine, College of Life Science, Shenzhen University, Shenzhen 518060, P. R. China. jzhanghappy@szu.edu.cn hezhendan@126.com.
3
The First Affiliated Hospital of Kunming Medical University, Kunming 650032, P. R. China.
4
School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, P. R. China. zhanghj@hkbu.edu.hk.

Abstract

There are many herbal teas that are found in nature that may be effective at treating the symptoms and also shortening the duration of viral infections. When combating viral infections, T lymphocytes are an indispensable part of human acquired immunity. However, studies on the use of natural products in stimulating lymphocyte-mediated interferon-gamma (IFN-γ) production are very limited. In this study, we found that acteoside, a natural phenylpropanoid glycoside from Kuding Tea, enhanced IFN-γ production in mouse lymphocytes in a dose-dependent manner, particularly in the CD4+ and CD8+ subsets of T lymphocytes. To this end, we suggest that the antiviral activity of acteoside was highly correlated to its inducing ability of IFN-γ production. Mechanistically, the activation of T-bet enhanced the promoter of IFN-γ and subsequently resulted in an increased IFN-γ production in T cells. Collectively, we have found a natural product with the capacity to selectively enhance mouse T cell IFN-γ production. Given the role of IFN-γ in the immune system, further studies to clarify the role of acteoside in inducing IFN-γ and prevention of viral infection are needed.

PMID:
27326537
DOI:
10.1039/c6fo00335d
[Indexed for MEDLINE]

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