Format

Send to

Choose Destination
Fundam Clin Pharmacol. 2016 Oct;30(5):476-82. doi: 10.1111/fcp.12209. Epub 2016 Aug 5.

Psychomotor developmental effects of prenatal exposure to psychotropic drugs: a study in EFEMERIS database.

Author information

1
Service de Pharmacologie Clinique, CHU de Toulouse, Inserm 1027, Université de Toulouse, 37 allées Jules Guesde, 31000, Toulouse, France.
2
Caisse Primaire d'Assurance Maladie de la Haute-Garonne, 3 Boulevard du Professeur Léopold Escande, 31500, Toulouse, France.
3
Protection Maternelle et Infantile, Conseil Général, 1 Boulevard de la Marquette, 31090, Toulouse, France.
4
Centre de diagnostic anténatal, CHU de Toulouse, Hôpital Paule de Viguier, 330 avenue de Grande Bretagne - TSA, 70034 - 31059, Toulouse, France.
5
Service de Pharmacologie Clinique, CHU de Toulouse, Inserm 1027, Université de Toulouse, 37 allées Jules Guesde, 31000, Toulouse, France. isabelle.lacroix@univ-tlse3.fr.

Abstract

Little is known about neurodevelopment of children exposed to psychotropic drugs during pregnancy. The purpose of this study was to evaluate the effects of prenatal exposure to psychotropic drugs on psychomotor development in children. This observational study used the EFEMERIS database. The database records the drugs prescribed and delivered during pregnancy and the resulting outcomes. Neurodevelopment at nine and 24 months of children born to women exposed to psychotropic drugs (anxiolytics, antidepressants, neuroleptics and anti-epileptics) during the second and/or third trimesters of pregnancy was compared to children who were not exposed to these drugs. Psychomotor development of 493 children (1.5%) exposed to psychotropic drugs during pregnancy was compared to 32 303 unexposed children. Exposure to psychotropic drugs during pregnancy was associated with an increased risk of abnormal motor development at 9 months (OR = 1.3 [1.1-2.2]) and abnormal motor and mental development at 24 months (OR = 4.8 [2.1-11.0] and OR = 2.3 [1.05-4.9]). Increased risk was observed in children born to women exposed to anti-epileptic drugs, neuroleptics or antidepressants during pregnancy. This study found a higher rate of deviation from the normal developmental milestones in children born to women exposed to psychotropic drugs during pregnancy and more particularly antidepressants, neuroleptics and anti-epileptics.

KEYWORDS:

EFEMERIS database; pregnancy; psychomotor development; psychotropic drugs

PMID:
27324073
DOI:
10.1111/fcp.12209
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center