Diagnostic value of plasma and bronchoalveolar lavage samples in acute lung allograft rejection: differential cytology

Respir Res. 2016 Jun 21;17(1):74. doi: 10.1186/s12931-016-0391-y.

Abstract

Diagnosis of acute lung allograft rejection is currently based on transbronchial lung biopsies. Additional methods to detect acute allograft dysfunction derived from plasma and bronchoalveolar lavage samples might facilitate diagnosis and ultimately improve allograft survival. This review article gives an overview of the cell profiles of bronchoalveolar lavage and plasma samples during acute lung allograft rejection. The value of these cells and changes within the pattern of differential cytology to support the diagnosis of acute lung allograft rejection is discussed. Current findings on the topic are highlighted and trends for future research are identified.

Keywords: Blood; Bronchoalveolar lavage; Cytology; Diagnosis; Graft rejection; Lung transplantation; Plasma.

Publication types

  • Review

MeSH terms

  • Acute Disease
  • Allografts
  • Animals
  • Biomarkers / blood*
  • Bronchoalveolar Lavage Fluid / chemistry*
  • Bronchoalveolar Lavage Fluid / cytology
  • Graft Rejection / blood
  • Graft Rejection / diagnosis*
  • Graft Rejection / metabolism*
  • Graft Rejection / pathology
  • Humans
  • Leukocytes / metabolism
  • Lung / metabolism*
  • Lung / pathology
  • Lung Transplantation / adverse effects*
  • Macrophages / metabolism
  • Predictive Value of Tests
  • Prognosis

Substances

  • Biomarkers