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Cell Physiol Biochem. 2016;39(1):115-22. doi: 10.1159/000445610. Epub 2016 Jun 20.

Protective Effect of Morocco Carob Honey Against Lead-Induced Anemia and Hepato-Renal Toxicity.

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1
Laboratory of Physiology, Pharmacology and Environmental Health. Faculty of Sciences Dhar Mahraz, University Sidi Mohamed Ben Abdallah, Fez, Morocco.

Abstract

BACKGROUND/AIMS:

Natural honey has many biological activities including protective effect against toxic materials. The aim of this study was to evaluate the protective effect of carob honey against lead-induced hepato-renal toxicity and lead-induced anemia in rabbits.

METHODS:

Twenty four male rabbits were allocated into four groups six rabbits each; group 1: control group, received distilled water (0.1 ml / kg.b.wt /daily); group 2: received oral lead acetate (2 g/kg.b.wt/daily); group 3: treated with oral honey (1g /kg.b.wt/daily) and oral lead (2 g/kg.b.wt/daily), and group 4: received oral honey (1 g/kg.b.wt/daily). Honey and lead were given daily during 24 days of experimentation. Laboratory tests and histopathological evaluations of kidneys were done.

RESULTS:

Oral administration of lead induced hepatic and kidney injury and caused anemia during three weeks of the exposure. Treatment with honey prevented hepato-renal lead toxicity and ameliorated lead-induced anemia when honey was given to animals during lead exposure.

CONCLUSION:

It might be concluded that honey has a protective effect against lead-induced blood, hepatic and renal toxic effects.

PMID:
27322825
DOI:
10.1159/000445610
[Indexed for MEDLINE]
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