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Nat Neurosci. 2016 Aug;19(8):1100-14. doi: 10.1038/nn.4332. Epub 2016 Jun 20.

The mouse cortico-striatal projectome.

Author information

1
USC Stevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging (LONI), Keck School of Medicine of University of Southern California, Los Angeles, California, USA.
2
Zilkha Neurogenetic Institute, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.
3
Center for Neurobehavioral Genetics, Semel Institute for Neuroscience &Human Behavior, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, USA.
4
Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California, USA.
5
Department of Neurology, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.

Abstract

Different cortical areas are organized into distinct intracortical subnetworks. The manner in which descending pathways from the entire cortex interact subcortically as a network remains unclear. We developed an open-access comprehensive mesoscale mouse cortico-striatal projectome: a detailed connectivity projection map from the entire cerebral cortex to the dorsal striatum or caudoputamen (CP) in rodents. On the basis of these projections, we used new computational neuroanatomical tools to identify 29 distinct functional striatal domains. Furthermore, we characterized different cortico-striatal networks and how they reconfigure across the rostral-caudal extent of the CP. The workflow was also applied to select cortico-striatal connections in two different mouse models of disconnection syndromes to demonstrate its utility for characterizing circuitry-specific connectopathies. Together, our results provide the structural basis for studying the functional diversity of the dorsal striatum and disruptions of cortico-basal ganglia networks across a broad range of disorders.

PMID:
27322419
PMCID:
PMC5564682
DOI:
10.1038/nn.4332
[Indexed for MEDLINE]
Free PMC Article

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