Format

Send to

Choose Destination
Thromb Res. 2016 Aug;144:123-6. doi: 10.1016/j.thromres.2016.06.016. Epub 2016 Jun 16.

Invasive pneumococcal disease leads to activation and hyperreactivity of platelets.

Author information

1
Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands; Center for Tropical and Infectious Diseases (CENTRID), Diponegoro University-Dr. Kariadi Hospital, Semarang, Indonesia. Electronic address: Rahajeng.Tunjungputri@radboudumc.nl.
2
Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
3
Central Veterinary Institute, Part of Wageningen UR, Lelystad, The Netherlands.
4
Department of Clinical Chemistry and Haematology, University Medical Centre, Utrecht, The Netherlands.
5
Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Clinical Chemistry and Haematology, University Medical Centre, Utrecht, The Netherlands.
6
Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

Abstract

Using a novel porcine model of intravenous Streptococcus pneumoniae infection, we showed that invasive pneumococcal infections induce marked platelet activation and hyperreactivity. This may contribute to the vascular complications seen in pneumococcal infection.

KEYWORDS:

Infection; Myocardial infarction; Platelet activation; Platelets; Pneumonia; Streptococcus pneumoniae

PMID:
27322088
DOI:
10.1016/j.thromres.2016.06.016
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center