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Biomarkers. 2017 May - Jun;22(3-4):268-278. doi: 10.1080/1354750X.2016.1204004. Epub 2016 Jul 11.

Circulating endothelium-enriched microRNA-126 as a potential biomarker for coronary artery disease in type 2 diabetes mellitus patients.

Author information

1
a College of Medicine and Medical Sciences , Arabian Gulf University , Manama , Kingdom of Bahrain.
2
b Diabetes and Endocrinology Clinic , Salmaniya Medical Complex , Manama , Kingdom of Bahrain.

Abstract

Circulating microRNAs (miRNAs) have been shown as promising biomarkers for various diseases. We investigated the predictive potential of circulating endothelium-enriched miR-126 in type 2 diabetes patients (T2D) without chronic complications and T2D patients with coronary artery diseases (CAD). The expression levels of circulating miR-126, determined by quantitative real time PCR, were decrease in peripheral blood of T2D patients and T2D with CAD compared with healthy controls. MiR-126 strongly associated with T2D and CAD, negatively correlated with LDL in CAD patients and differentiated between T2D patients, T2D patients with CAD and healthy subjects. Circulating miR-126 may serve as a biomarker for predicting patients with T2D and diabetic CAD.

KEYWORDS:

Biomarker; circulating miR-126; coronary artery disease; microRNAs; type 2 diabetes

PMID:
27321479
DOI:
10.1080/1354750X.2016.1204004
[Indexed for MEDLINE]

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