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Rev Esp Med Nucl Imagen Mol. 2016 Nov - Dec;35(6):394-397. doi: 10.1016/j.remn.2016.05.002. Epub 2016 Jun 16.

18F-FDG PET/CT and functional MRI in a case of crossed logopenic primary progressive aphasia.

[Article in English, Spanish]

Author information

1
Servicio de Medicina Nuclear, Hospital Clínico San Carlos, Universidad Complutense, Instituto de Investigación Sanitaria San Carlos, Madrid, España. Electronic address: mncabreram@hotmail.com.
2
Servicio de Neurología, Hospital Clínico San Carlos, Universidad Complutense, Instituto de Investigación Sanitaria San Carlos, Madrid, España.
3
Servicio de Radiodiagnóstico, Hospital Clínico San Carlos, Universidad Complutense, Instituto de Investigación Sanitaria San Carlos, Madrid, España.
4
Servicio de Medicina Nuclear, Hospital Clínico San Carlos, Universidad Complutense, Instituto de Investigación Sanitaria San Carlos, Madrid, España.

Abstract

Primary progressive aphasia is a clinical syndrome caused by a neurodegeneration of areas and neural networks involved in language, usually in the left hemisphere. The term "crossed aphasia" denotes an acquired language dysfunction caused by a lesion in the hemisphere ipsilateral to the dominant hand. A case is presented on a 75-year-old right-handed woman with a logopenic variant of primary progressive aphasia with word-finding difficulties of 2 years onset. The 18F-FDG PET/CT showed right temporoparietal hypometabolism. A functional MRI scan was performed during a verb naming task in order to characterise language lateralisation patterns. A similar activation pattern was observed in both hemispheres, with less activation than expected in bilateral inferior frontal gyrus. These findings support that logopenic variant of primary progressive aphasia should not be considered as a neurodegeneration starting in the left brain hemisphere, but as a syndrome characterised by asymmetric neurodegeneration of brain regions and neural networks involved in language.

KEYWORDS:

(18)F-FDG PET-CT; Afasia cruzada; Afasia progresiva primaria variante logopénica; Crossed aphasia; Functional MRI; Language lateralization; Lateralización del lenguaje; Logopenic variant of primary progressive aphasia; PET-TC (18)F-FDG; RM funcional

PMID:
27321169
DOI:
10.1016/j.remn.2016.05.002
[Indexed for MEDLINE]
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