Format

Send to

Choose Destination
Nat Commun. 2016 Jun 20;7:11914. doi: 10.1038/ncomms11914.

KRT14 marks a subpopulation of bladder basal cells with pivotal role in regeneration and tumorigenesis.

Author information

1
Center for Basic Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
2
Laboratory of Cellular Immunology, Center for Basic Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.

Abstract

The urothelium is a specialized epithelium that lines the urinary tract. It consists of three different cell types, namely, basal, intermediate and superficial cells arranged in relatively distinct cell layers. Normally, quiescent, it regenerates fast upon injury, but the regeneration process is not fully understood. Although several reports have indicated the existence of progenitors, their identity and exact topology, as well as their role in key processes such as tissue regeneration and carcinogenesis have not been clarified. Here we show that a minor subpopulation of basal cells, characterized by the expression of keratin 14, possesses self-renewal capacity and also gives rise to all cell types of the urothelium during natural and injury-induced regeneration. Moreover, these cells represent cells of origin of urothelial cancer. Our findings support the hypothesis of basally located progenitors with profound roles in urothelial homoeostasis.

PMID:
27320313
PMCID:
PMC4915139
DOI:
10.1038/ncomms11914
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center