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Clin Imaging. 2016 Jul-Aug;40(4):732-8. doi: 10.1016/j.clinimag.2016.02.018. Epub 2016 Feb 23.

Assessment of severity of leukoaraiosis: a diffusional kurtosis imaging study.

Author information

1
Department of Radiology, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, Fujian 362000, China.
2
Department of Radiology, Shishi City Hospital, Quanzhou, Fujian 362700, China.
3
Department of Radiology, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, 350005, China.
4
Department of Radiology, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, Fujian 362000, China. Electronic address: 2310611338@qq.com.
5
GE Healthcare China, Guangzhou 510623, China.

Abstract

OBJECTIVE:

The objective was to investigate the capabilities of diffusional kurtosis imaging (DKI) in detection of age-related white matter (WM) changes in elderly patients with leukoaraiosis.

MATERIAL AND METHODS:

Fractional anisotropy (FA), kurtosis, and diffusion parameters in the frontal lobe and parietal lobe were compared between 14 patients at Fazekas scale 0 and 1, and 15 patients at Fazekas scale 2 and 3.

RESULTS:

FA and DKI parameters were significantly altered in the ischemic lesions vs normal regions of WM in the severe patients.

CONCLUSION:

DKI can provide sensitive imaging biomarkers for assessing the severity of leukoaraiosis in reference to Fazekas score.

KEYWORDS:

DKI; Diffusion; Kurtosis; Leukoaraiosis; Non-Gaussians

PMID:
27317218
DOI:
10.1016/j.clinimag.2016.02.018
[Indexed for MEDLINE]

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