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Psychiatry J. 2016;2016:7146341. doi: 10.1155/2016/7146341. Epub 2016 May 30.

Towards a Standard Psychometric Diagnostic Interview for Subjects at Ultra High Risk of Psychosis: CAARMS versus SIPS.

Author information

1
Institute of Psychiatry Psychology and Neuroscience (IoPPN), King's College London, London SE5 8AF, UK; OASIS Service, South London and Maudsley NHS Foundation Trust, London SE11, UK.
2
Institute of Psychiatry Psychology and Neuroscience (IoPPN), King's College London, London SE5 8AF, UK.
3
Department of Psychiatry, Seoul National University College of Medicine, Seoul 08826, Republic of Korea.
4
Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge CB21 5HH, UK.
5
Real-Time Systems Laboratory, Scuola Superiore Sant'Anna, 56124 Pisa, Italy.
6
OASIS Service, South London and Maudsley NHS Foundation Trust, London SE11, UK.
7
Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge CB21 5HH, UK; Department of Psychiatry, University of Cambridge, Cambridge CB2 0SZ, UK.

Abstract

BACKGROUND:

Several psychometric instruments are available for the diagnostic interview of subjects at ultra high risk (UHR) of psychosis. Their diagnostic comparability is unknown.

METHODS:

All referrals to the OASIS (London) or CAMEO (Cambridgeshire) UHR services from May 13 to Dec 14 were interviewed for a UHR state using both the CAARMS 12/2006 and the SIPS 5.0. Percent overall agreement, kappa, the McNemar-Bowker χ (2) test, equipercentile methods, and residual analyses were used to investigate diagnostic outcomes and symptoms severity or frequency. A conversion algorithm (CONVERT) was validated in an independent UHR sample from the Seoul Youth Clinic (Seoul).

RESULTS:

There was overall substantial CAARMS-versus-SIPS agreement in the identification of UHR subjects (n = 212, percent overall agreement = 86%; kappa = 0.781, 95% CI from 0.684 to 0.878; McNemar-Bowker test = 0.069), with the exception of the brief limited intermittent psychotic symptoms (BLIPS) subgroup. Equipercentile-linking table linked symptoms severity and frequency across the CAARMS and SIPS. The conversion algorithm was validated in 93 UHR subjects, showing excellent diagnostic accuracy (CAARMS to SIPS: ROC area 0.929; SIPS to CAARMS: ROC area 0.903).

CONCLUSIONS:

This study provides initial comparability data between CAARMS and SIPS and will inform ongoing multicentre studies and clinical guidelines for the UHR psychometric diagnostic interview.

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