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Oxid Med Cell Longev. 2016;2016:9651236. doi: 10.1155/2016/9651236. Epub 2016 May 25.

Resveratrol: A Potential Hippocampal Plasticity Enhancer.

Author information

1
Translational Neurobiology Unit, Laboratory of Panic & Respiration/Institute of Psychiatry, Universidade Federal do Rio de Janeiro, Avenida Venceslau Brás, 71 Fundos, 22290-140 Praia Vermelha, RJ, Brazil.
2
Department of Basic and Clinical Neuroscience/Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 9NU, UK; The Maurice Wohl Clinical Neuroscience Institute, 125 Coldharbour Lane, London SE5 9NU, UK.
3
Translational Neurobiology Unit, Laboratory of Panic & Respiration/Institute of Psychiatry, Universidade Federal do Rio de Janeiro, Avenida Venceslau Brás, 71 Fundos, 22290-140 Praia Vermelha, RJ, Brazil; Health and Environment School, Universidade Castelo Branco, Avenida de Santa Cruz 1631, 21710-255 Realengo, RJ, Brazil.

Abstract

The search for molecules capable of restoring altered hippocampal plasticity in psychiatric and neurological conditions is one of the most important tasks of modern neuroscience. It is well established that neural plasticity, such as the ability of the postnatal hippocampus to continuously generate newly functional neurons throughout life, a process called adult hippocampal neurogenesis (AHN), can be modulated not only by pharmacological agents, physical exercise, and environmental enrichment, but also by "nutraceutical" agents. In this review we focus on resveratrol, a phenol and phytoalexin found in the skin of grapes and red berries, as well as in nuts. Resveratrol has been reported to have antioxidant and antitumor properties, but its effects as a neural plasticity inducer are still debated. The current review examines recent evidence implicating resveratrol in regulating hippocampal neural plasticity and in mitigating the effects of various disorders and diseases on this important brain structure. Overall, findings show that resveratrol can improve cognition and mood and enhance hippocampal plasticity and AHN; however, some studies report opposite effects, with resveratrol inhibiting aspects of AHN. Therefore, further investigation is needed to resolve these controversies before resveratrol can be established as a safe coadjuvant in preventing and treating neuropsychiatric conditions.

PMID:
27313836
PMCID:
PMC4897722
DOI:
10.1155/2016/9651236
[Indexed for MEDLINE]
Free PMC Article

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