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Dis Markers. 2016;2016:3841927. doi: 10.1155/2016/3841927. Epub 2016 May 22.

Plasma miR-10a: A Potential Biomarker for Coronary Artery Disease.

Author information

1
Department of Cardiology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong 519000, China.

Abstract

AIMS:

MicroRNAs (miRNAs) are involved in the pathogenesis of coronary artery disease (CAD). The objective of this study is to determine plasma levels of miR-10a in CAD and analyze its association with the severity of CAD.

MATERIALS AND METHODS:

Plasma miR-10a levels in 60 CAD patients including stable angina pectoris (SAP) (n = 29), unstable angina pectoris (UAP) or non-ST elevation myocardial infarction (MI) (NSTEMI) (n = 17), or ST elevation MI (STEMI) (n = 14) and 20 non-CAD subjects were assessed by real-time polymerase chain reaction (qRT-PCR), and associations of miR-10a levels with risk factors of CAD and its severity were analyzed.

RESULTS:

The qRT-PCR results showed that plasma miR-10a levels were decreased in CAD patients, and CAD with high SYNTAX scores or STEMI was significantly associated with lower miR-10a levels.

CONCLUSIONS:

Lower plasma miR-10a levels were negatively associated with the presence as well as severity of CAD, and plasma miR-10a can act as a potential biomarker for estimating the presence and severity of CAD.

PMID:
27313333
PMCID:
PMC4893451
DOI:
10.1155/2016/3841927
[Indexed for MEDLINE]
Free PMC Article

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