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Genes Dev. 2016 Jun 15;30(12):1389-94. doi: 10.1101/gad.277756.116. Epub 2016 Jun 16.

The adrenal capsule is a signaling center controlling cell renewal and zonation through Rspo3.

Author information

1
Institute of Biology Valrose, Université de Nice-Sophia, F-06108 Nice, France; UMR1091, Institut National de la Santé et de la Recherche Médicale, F-06108 Nice, France; CNRS, UMR7277, F-06108 Nice, France;
2
UMR6293, Centre National de la Recherche Scientifique, Clermont Université, F-63178 Aubière, France; U1103, Institut National de la Santé et de la Recherche Médicale, Clermont Université, F-63178 Aubière, France;
3
Biocenter Oulu, 90220 Oulu, Finland;
4
Beatson Institute, Glasgow G61 1BD, United Kingdom.

Abstract

Adrenal glands are zonated endocrine organs that are essential in controlling body homeostasis. How zonation is induced and maintained and how renewal of the adrenal cortex is ensured remain a mystery. Here we show that capsular RSPO3 signals to the underlying steroidogenic compartment to induce β-catenin signaling and imprint glomerulosa cell fate. Deletion of RSPO3 leads to loss of SHH signaling and impaired organ growth. Importantly, Rspo3 function remains essential in adult life to ensure replenishment of lost cells and maintain the properties of the zona glomerulosa. Thus, the adrenal capsule acts as a central signaling center that ensures replacement of damaged cells and is required to maintain zonation throughout life.

KEYWORDS:

R-spondin signaling; adrenal zonation; mouse models; organ maintenance; β-catenin signaling

PMID:
27313319
PMCID:
PMC4926862
DOI:
10.1101/gad.277756.116
[Indexed for MEDLINE]
Free PMC Article

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