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Clin Infect Dis. 2016 Oct 1;63(7):954-958. doi: 10.1093/cid/ciw398. Epub 2016 Jun 16.

High Rates of Nonsusceptibility to Ceftazidime-avibactam and Identification of New Delhi Metallo-β-lactamase Production in Enterobacteriaceae Bloodstream Infections at a Major Cancer Center.

Author information

1
Division of Pharmacy.
2
Department of Pharmacy Practice and Translational Research, University of Houston College of Pharmacy, Texas.
3
Department of Laboratory Medicine.
4
JMI Laboratories, North Liberty, Iowa.
5
Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas MD Anderson Cancer Center.

Abstract

Resistance to the novel β-lactam/β-lactamase inhibitor combination ceftazidime-avibactam (CAZ-AVI) among carbapenem-resistant Enterobacteriaceae (CRE) has infrequently been reported in the United States. We report unexpectedly high rates of resistance to CAZ-AVI in CRE bloodstream isolates at our institution associated with the nonoutbreak spread of New Delhi metallo-β-lactamase in diverse Enterobacteriaceae species.

KEYWORDS:

CRE; NDM; bacteremia; carbapenemase; ceftazidime-avibactam

PMID:
27313265
DOI:
10.1093/cid/ciw398
[Indexed for MEDLINE]

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