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Cancer Immunol Res. 2016 Aug;4(8):679-87. doi: 10.1158/2326-6066.CIR-16-0031. Epub 2016 Jun 16.

Immune Profiling of Adenoid Cystic Carcinoma: PD-L2 Expression and Associations with Tumor-Infiltrating Lymphocytes.

Author information

1
Department of Radiation Oncology, Brigham and Women's Hospital/Dana-Farber Cancer Center, Boston, Massachusetts. Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Boston, Massachusetts.
2
Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts.
3
Department of Medical Oncology, Brigham and Women's Hospital/Dana-Farber Cancer Center, Boston, Massachusetts.
4
Center for Immuno-Oncology, Brigham and Women's Hospital/Dana-Farber Cancer Center, Boston, Massachusetts.
5
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
6
Center for Immuno-Oncology, Brigham and Women's Hospital/Dana-Farber Cancer Center, Boston, Massachusetts. Department of Medical Oncology, Brigham and Women's Hospital/Dana-Farber Cancer Center, Boston, Massachusetts.
7
Department of Pathology, Brigham and Women's Hospital/Dana-Farber Cancer Center, Boston, Massachusetts.
8
Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
9
Department of Radiation Oncology, Brigham and Women's Hospital/Dana-Farber Cancer Center, Boston, Massachusetts. jdschoenfeld@partners.org.

Abstract

Adenoid cystic carcinoma (ACC) is among the most lethal salivary gland tumors, with no treatments for metastatic disease that prolong survival. We examined tissue from 28 primary and metastatic ACC deposits obtained from 21 patients for infiltrating immune cells and PD-L1/PD-L2 expression and determined mRNA profiles of over 1,400 oncogenic and immune-related genes. We also assessed the effect of chemoradiation on immune mediators in a patient who had serial biopsies available. Most tumors expressed PD-L2 but had few infiltrating immune cells. Lack of immune-cell infiltrate was associated with expression of genes in the β-catenin/Wnt and PI3K pathways. Additionally, certain transcripts linked to growth and invasion were differentially expressed among primary and metastatic deposits. Chemoradiation appeared to increase CD8(+) effector T cells, decrease regulatory T cells, and promote a systemic humoral response. These data suggest a potential role for PD-L2 inhibition and immune modulation as treatment for patients with ACC. Cancer Immunol Res; 4(8); 679-87.

PMID:
27312343
DOI:
10.1158/2326-6066.CIR-16-0031
[Indexed for MEDLINE]
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