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J Urol. 2016 Nov;196(5):1486-1492. doi: 10.1016/j.juro.2016.06.018. Epub 2016 Jun 14.

Heritability of Lower Urinary Tract Symptoms in Men: A Twin Study.

Author information

1
VA Center of Excellence for Stress and Mental Health and the University of California, San Diego, San Diego, California. Electronic address: nafari@ucsd.edu.
2
VA Center of Excellence for Stress and Mental Health and the University of California, San Diego, San Diego, California.
3
Vietnam Era Twin Registry, Seattle Epidemiologic Research and Information Center, VA Puget Sound Health Care System, Seattle, Washington.
4
Vietnam Era Twin Registry, Seattle Epidemiologic Research and Information Center, VA Puget Sound Health Care System, Seattle, Washington; University of Washington, Seattle, Washington.
5
Elson S. Floyd College of Medicine, Washington State University, Seattle and Spokane, Washington.
6
University of Washington, Seattle, Washington.

Abstract

PURPOSE:

Symptoms of urinary irritation, urgency, frequency and obstruction, known as lower urinary tract symptoms, are common in urological practice. However, little is known about the etiology or pathogenesis of lower urinary tract symptoms, especially the relative contributions of genetic and environmental factors to the development of these symptoms. We used a classic twin study design to examine the relative contributions of genetic and environmental factors to the occurrence of lower urinary tract symptoms in middle-aged men.

MATERIALS AND METHODS:

Twins were members of the Vietnam Era Twin Registry. We used a mail survey to collect data on lower urinary tract symptoms using the I-PSS (International Prostate Symptom Score) instrument. Twin correlations and biometric modeling were used to determine the relative genetic and environmental contributions to variance in I-PSS total score and individual items.

RESULTS:

Participants were 1,002 monozygotic and 580 dizygotic middle-aged male twin pairs (mean age 50.2 years, SD 3.0). Nearly 25% of the sample had an I-PSS greater than 8, indicating at least moderate lower urinary tract symptoms. The heritability of the total I-PSS was 37% (95% CI 32-42). Heritability estimates ranged from 21% for nocturia to 40% for straining, with moderate heritability (34% to 36%) for urinary frequency and urgency.

CONCLUSIONS:

Genetic factors provide a moderate contribution (20% to 40%) to lower urinary tract symptoms in middle-aged men, suggesting that environmental factors may also contribute substantially to lower urinary tract symptoms. Future research is needed to define specific genetic and environmental mechanisms that underlie the development of these symptoms and conditions associated with lower urinary tract symptoms.

KEYWORDS:

heritable; lower urinary tract symptoms; quantitative trait; twins

Comment in

PMID:
27312318
PMCID:
PMC5069121
DOI:
10.1016/j.juro.2016.06.018
[Indexed for MEDLINE]
Free PMC Article

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