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J Asian Nat Prod Res. 2017 Jan;19(1):47-52. doi: 10.1080/10286020.2016.1196672. Epub 2016 Jun 16.

Chemical constituents from the rhizome of Polygonum paleaceum and their antifungal activity.

Author information

1
a School of Pharmacy , Second Military Medical University , Shanghai 200433 , China.
2
b School of Medicine , Tongji University , Shanghai 200092 , China.

Abstract

A new compounds neopaleaceolactoside (1), along with nine known compounds phyllocoumarin (2), quercetin (3), quercitrin (4), quercetin-3-methyl ether (5), vincetoxicoside B (6), isoquercitrin (7), kaempferol (8), (-)-epicatechin (9), and chlorogenic acid (10), was isolated from Polygonum paleaceum Wall. Their chemical structures were established based on one-dimensional and two-dimensional nuclear magnetic resonance techniques, mass spectrometry and by comparison with spectroscopic data reported. Some selected compounds were screened for their antifungal activity. Quercetin (3), vincetoxicoside B (6), kaempferol (8), and (-)-epicatechin (9) showed synergistic antifungal activities with the FICI values <0.5. A preliminary structure-activity relationship could be observed that free 3-OH in the structure of flavonoids was important for synergistic antifungal activity.

KEYWORDS:

Polygonaceae; Polygonum paleaceum; antifungal activity; flavonoids; synergist

PMID:
27309618
DOI:
10.1080/10286020.2016.1196672
[Indexed for MEDLINE]
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