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Mol Cell Oncol. 2016 Mar 16;3(2):e1105353. doi: 10.1080/23723556.2015.1105353. eCollection 2016 Mar.

More challenges ahead-metabolic heterogeneity of pancreatic cancer stem cells.

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Centre for Stem Cells in Cancer & Ageing, Barts Cancer Institute, Queen Mary University of London , UK.


Pancreatic cancer stem cells (CSCs) display a distinct metabolic phenotype based on their strong dependence on mitochondrial oxidative phosphorylation (OXPHOS) and limited metabolic plasticity. While suppression of MYC upstream of PGC-1α was the key determinant of this phenotype, we also identified a subset of CSCs with reduced mitochondrial content that showed resistance to mitochondrial targeting, but could be sensitized by inhibition of MYC.


Cancer stem cells; metabolism; metformin; pancreatic ductal adenocarcinoma

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