MicroRNAs-from metastasis prediction to metastasis prevention?

Mol Cell Oncol. 2015 Dec 10;3(2):e1074336. doi: 10.1080/23723556.2015.1074336. eCollection 2016 Mar.

Abstract

Recently, we suggested the microRNA (miR) landscape defining metastasis. The first miR-driven network orchestrating invasion, intravasation, and metastasis was confirmed independently across several malignancies, suggesting a rather general principle for metastasis regulation. We hope that our data will stimulate the field in terms of further hypothesis generation, metastasis prediction, and metastasis prevention.

Keywords: Cancer; EMT; FOXN3; metastasis; microRNA; stem cell.