SESTRINs regulate mTORC1 via RRAGs: The riddle of GATOR

Andrei V Budanov

doi:10.1080/23723556.2014.997113

SESTRINs regulate mTORC1 via RRAGs: The riddle of GATOR

Mol Cell Oncol. 2015 Jan 23;2(3):e997113. doi: 10.1080/23723556.2014.997113. eCollection 2015 Jul-Sep.

Author

Andrei V Budanov¹

Affiliation

¹ Department of Human and Molecular Genetics; Goodwin Research Laboratories; Massey Cancer Center; Virginia Commonwealth University ; Richmond, VA, USA.

Abstract

SESTRINs, proteins encoded by the SESN1-3 genes in mammals, are well-established suppressors of the mechanistic target of rapamycin complex 1 (mTORC1) kinase. Recently, we found that SESTRINs bind the GATOR2 protein complex, which is a regulator of RRAGA/B guanosine triphosphatase. Three independent studies support the RRAGA/B-dependence of mTORC1 regulation by SESTRINs; however, the role of GATOR2 in this process requires clarification.

Keywords: GATOR; GID; RRAG-A/B; SESTRINs; mTORC1.