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Mol Cell Oncol. 2015 Apr 18;2(3):e980134. doi: 10.4161/23723556.2014.980134. eCollection 2015 Jul-Sep.

TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling.

Author information

1
Department of Biochemistry and Molecular Biology I; School of Biology; Complutense University; Madrid, Spain; Instituto de Investigaciones Sanitarias San Carlos (IdISSC); Madrid, Spain.
2
Department of Biochemistry and Molecular Biology I; School of Biology; Complutense University ; Madrid, Spain.
3
Department of Biochemistry and Molecular Biology I; School of Biology; Complutense University; Madrid, Spain; Instituto de Investigación Hospital 12 de Octubre (I+12); Madrid, Spain.
4
CIC bioGUNE, Bizkaia Technology Park ; Derio, Spain.
5
Department of Animal Surgery and Medicine; School of Veterinary; Complutense University ; Madrid, Spain.
6
Institute of Biophysics; Hungarian Academy of Sciences ; Szeged, Hungary.
7
CIC bioGUNE-CIBERehd, Bizkaia Technology Park ; Derio, Spain.
8
Instituto de Investigaciones Biomédicas Alberto Sols; Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM) ; Madrid, Spain.
9
Centre de Recherche en Carcérologie de Marseille (CRCM); INSERM UMR 1068, CNRS UMR 7258, Aix Marseille Université and Institut Paoli Calmette ; Marseille, France.
10
Department of Biochemistry and Molecular Biology I; School of Biology; Complutense University; Madrid, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) and Instituto Ramón y Cajal de Investigaciones Sanitarias (IRYCIS); Madrid, Spain.
11
Department of Cardiovascular Science; University of Sheffield ; Sheffield, UK.
12
CIC bioGUNE, Bizkaia Technology Park; Derio, Spain; Ikerbasque, Basque Foundation for Science; Bilbao, Spain; Biochemistry and Molecular Biology Department; University of the Basque Country (UPV/EHU); Bilbao, Spain.

Abstract

In a recent article, we found that Tribbles pseudokinase 3 (TRIB3) plays a tumor suppressor role and that this effect relies on the dysregulation of the phosphorylation of v-akt murine thymoma viral oncogene homolog (AKT) by the mammalian target of rapamycin complex 2 (mTORC2 complex), and the subsequent hyperphosphorylation and inactivation of the transcription factor Forkhead box O3 (FOXO3).

KEYWORDS:

PTEN; Tribbles pseudokinases; animal models of cancer; prostate cancer; skin carcinogenesis

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